Friday, September 28, 2012

B-cell lymphocytes family, which produce antibodies. Some (effector cells, plasma forplas cells) pl


Removing mutation - deletion from the database forplas to act reading frame, which causes most cases of a complete change of proteins.
Coup glutamine forplas Llewellyn, hydrophobic amino acids, which appears on the surface of the protein. Created a chain reaction - meets hydrophobic hydrophobic, and deposition of hemoglobin in red blood cells. forplas This crisis of sickle-cell change cell shape and causes Llizis cells, forplas which leads to the least active blood cells that can carry oxygen.
Most Hhmoglovinim mutant (about 95%) is the replacement of only one amino acid. Mutants have not changed anything, and those that can cause severe disease. forplas Some types of the disease called "thalassemia" - Deficit one chain of hemoglobin. Thalassemia can be caused by deletion or mutation forplas of the frame.
IGG - IMUNOGLOBIN.
Their quarterly structure consists of four chains - two heavy and two light. Chains connected forplas by disulfide bonds between them. Relevant Lhantign (bacteria or virus) called FAB. It is associated with bacteria forplas called FC.
These molecules are also referred to as antigenic determinants. An antigen is defined as capable of provoking forplas reaction of the immune forplas system. It could also be a virus, bacteria or a small protein. Antibodies forplas can be tied to a specific antigen. Antigen could not context antigen - is a special area called antigenic determinants that bind with high affinity antibodies. When you look for antibodies, both hands bound to the same antigen. Antibody may cause a reduction and elimination of antigen (when connected together).
B-cell lymphocytes family, which produce antibodies. Some (effector cells, plasma forplas cells) plays an important role in the production of antigen alone - and some of them can be used as memory elements in immune memory cells, if the body will respond antigen in the future.
Creation forplas of antibodies
in response to "Humorlit". It is a term that corresponds to the cellular response forplas (cellular forplas response). Cellular responses mediated by other cell types, including T lymphocytes sellers. If antibodies to freely roam the blood and bind antigens, cell response
is more dynamic and smart: he uses the communication between cells.
Example: cancer develops in our body (not from an external source) and carcinoma can invade many places in the body and does not always seem to matter what part of the body's cells. What changes in cancer cell production model protein. If a normal cell produces a certain amount of certain proteins, cancer cells produce these proteins forplas and other quantities. T cells can "ask" the cancer cells identity. If they detect cells of the patient or suppressed virus cells are perforated with bullets (Frforin).
ID cells called MHC. Form tray appears on the surface of our cells in the body except red blood cells. MHC peptide protein has a size of 9 amino acids of protein sources - cells. Fusion protein - protein cells may be more pronounced (as in the case of cancer cells). Model proteins in cancerous changes, and peptides derived from proteins cells look different on the surface of cells. T cells comes and binds to MOE on T-cell receptor (all T cells in the body is). If the peptide standard, T leaf cells. If the cancer peptide, T cells attack the same cell.
Catalyst is the acceleration of a chemical reaction without itself changing. Most biological catalysts enzymes. The enzyme acts on the substrate forplas (Sovstrat). Enzymes can accelerate the reaction by several orders of magnitude - from 100 to 1000 and even billions of times!
Every chemical reaction must pass the energy barrier should be applied (delta G must be negative). This enzyme reduces the activation energy of a chemical reaction. Because it is a chemical reaction, forplas factors such as pH and temperature forplas influence: Heating can help at the point where the enzyme works optimally maximum efficiency. If we heat more efficient from this point down because Dntortzih. Equilibrium does not change - it is the same, but faster.
Many enzymes are able to act, changing pad that between them. Intermediate state has a lower free energy (not as low as the output forplas and lower substrate). At low free energy intermediates.
Substrate and enzyme adapt to each other. This enzyme is not Nzaim Just substrate. When the substrate binds to the enzyme, the shape of the enzyme. Conformational changes make the proper connection of the active centers of the enzyme that promotes the enzymatic reaction. forplas When the product is released enzyme returns to its original shape.
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